Viagra Patient Tips

It's the most speculative use for sildenafil, and it's far from clinical application. Still, it's an interesting area of new research.

5.5 Hypotension when Co-administered with Alpha-blockers or Anti-hypertensives

And a 2006 study of 40 Raynaud's patients reported similar benefits from vardenafil in a dose of 10 mg twice a day. Sildenafil was discovered by scientists looking for a new medication to dilate coronary arteries. It does that, but because it widens healthy coronary arteries more than diseased vessels, it has not been successful in treating angina. But it may have other benefits for cardiac patients. In the first years of the Viagra era, research on sildenafil and the heart was devoted to making sure the drug was safe for the circulation. A European study of 25 men who had erectile dysfunction but no other circulatory disorders found that blood vessels in the brain responded to stress better after a 50-mg dose of sildenafil.

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More interesting results were reported by scientists in Michigan, who produced ischemic strokes in rats by temporarily blocking blood vessels.

What should I know about storage and disposal of this medication?

In turn, low oxygen produces a narrowing of the pulmonary arteries. The heart must therefore work harder, reducing the capacity to exercise. To find out if it might improve exercise capacity in low oxygen conditions, scientists tested 14 healthy mountain climbers in a lab in Germany and again at a Mount Everest base camp. In the lab, the volunteers breathed 10% oxygen through a mask; on the mountain, they breathed natural air. Under both conditions, a 50-mg sildenafil tablet decreased pressures in the lungs' blood vessels and increased the maximum exercise capacity.

What are the typical dosages of Viagra?

It's a small study, and it's too soon to say if sildenafil will help prevent or treat acute mountain sickness. Still, a study of 29 climbers reported that tadalafil can also reduce pulmonary artery pressure at a high altitude. In affected individuals, exposure to the cold triggers spasm of the small arteries that supply blood to the fingers, toes, or both. Temporarily deprived of adequate blood flow, the involved digits become pale, cold, and very painful. It's a common condition, affecting up to 8% of men and 17% of women.

How is sildenafil supplied (dosage forms)?

In the vast majority, there are no underlying diseases (primary Raynaud's), and patients do well simply by minimizing their exposure to cold. But secondary Raynaud's can complicate collagen-vascular diseases or certain other conditions. It's not common, but secondary Raynaud's can be very painful and difficult to treat. Many medications have been used without consistent success. But a 2005 study of 16 patients with severe Raynaud's phenomenon that had not responded to other medications reported benefit from sildenafil in a dose of 50 mg twice a day. During their recovery, the animals were divided into three groups.

Drug Category	Interaction Effect	Recommended Action
Nitrates	Severe hypotension risk	Avoid concomitant use
Alpha-blockers	Additive blood pressure lowering	Consult doctor before combined use
CYP3A4 inhibitors	Increased Viagra levels	Dose adjustment or avoid
Other PDE5 inhibitors	Possible overdose effects	Do not combine without medical advice

One received no treatment, another low-dose sildenafil, and the third high-dose sildenafil. The animals who got sildenafil recovered better, with the highest doses producing the best results. The scientists concluded that the medication actually stimulated the growth of new nerve cells in the brain tissue next to the stroke damage.

• Remember that Viagra does not protect against sexually transmitted diseases.
• Use contraception if necessary, as Viagra does not affect fertility.
• Alcohol consumption can diminish Viagra's effects.
• Always follow the prescribed instructions carefully.
• Viagra is most effective when taken on an empty stomach or with light food.
• Lifestyle factors like smoking can impact its effectiveness.
• Not suitable for men with severe liver or kidney conditions.
• Open communication with your healthcare provider optimizes treatment.

It's far too early to know whether sildenafil may someday help people with strokes. If you get your information about sildenafil from Super Bowl commercials or e-mail spam, you might dismiss it as a lifestyle drug of little real medical importance.

Other targets: Therapeutic roles

The most important worry about ED pills is their ability to widen arteries enough to lower blood pressure. It's rarely a problem in healthy men, but it explains a crucial precaution that applies to all three medications. Nitrates are medications that temporarily widen arteries by increasing their supply of nitric oxide. That's how they widen partially blocked coronary arteries in patients with angina. But because the nitrates and ED pills all act on nitric oxide, they do not mix.

What are the most common side effects of sildenafil?

Men who are taking nitrates should never use any of the ED pills. This ban includes all preparations of nitroglycerin (short-acting, under-the-tongue tablets or sprays); long-acting nitrates (isosorbide dinitrate, or Isordil, Sorbitrate, and others, and isosorbide mononitrate, Imdur, ISMO, and others); nitroglycerin patches and pastes; and amyl nitrite (so-called poppers, used for sexual stimulation by some men). ED pills are quite safe for men with stable cardiovascular disease who do not take nitrates. This group includes patients with stable angina, previous heart attacks, mild congestive heart failure, well-controlled hypertension, and previous strokes. But men with recent heart attacks and strokes should wait until they have recovered fully, and patients with unstable blood pressure, active angina, or any other complex or unusual problem should hold off and get specific medical guidance.

Less common

And men who take alpha blockers (particularly terazosin, or Hytrin, and doxazosin, or Cardura) for hypertension or benign prostatic hyperplasia (BPH) should use ED pills (particularly vardenafil or tadalafil) with great caution, if at all. Studies also suggest that sildenafil may increase respiratory distress in men with severe sleep apnea and that it slows gallbladder function, which might increase the risk of gallstones. Scientists who noticed that the ED pills can produce side effects in many parts of the body are asking if they can also serve therapeutic roles beyond male (or female) sexuality. Because of its seniority, most of the research has used sildenafil, so it's not clear if the newer medications will fill similar roles. But for sildenafil, at least, some new uses appear promising. In fact, it's a serious prescription medication that has helped millions of men who are distressed by an entirely legitimate medical problem.

• Cost savings may be associated with daily Viagra compared to on-demand.
• Effective for men seeking constant support for erectile issues.
• Combining daily Viagra with healthy lifestyle choices can improve results.
• Patient education is crucial for safe use.
• Viagra daily is sometimes combined with other ED treatments.
• The medication helps maintain blood flow during overnight or daytime.
• Sexual activity frequency can increase with daily use.
• Discuss concerns about dependence or psychological effects with your doctor.

Because the drug acts on arteries beyond the penis, it can produce various side effects.

2. Timing matters.

But small amounts of PDE-5 are found in blood vessels in other parts of the body. In addition, PDE-5 is just one of 11 enzymes in the phosphodiesterase family. The others are concentrated in different parts of the body. While the ED pills have a much greater affinity for PDE-5 than the other PDEs, they have some ability to inhibit those closely related enzymes. Both factors explain why the ED pills sometimes produce side effects in many parts of the body.

Factors that affect how long Viagra lasts

The most common side effects are headaches and facial flushing, which occur in about 15% of men. Other reactions include nasal congestion, indigestion, and back pain; blue-tinged vision is even less common. In almost every case, these side effects are mild and transient. But new information has added a rare eye disease to the list. Nonarteritic anterior ischemic optic neuropathy (NAION) is a poorly understood disorder that can cause blindness.

1. Don’t eat a heavy meal beforehand

In March 2005, doctors reported that seven men experienced visual impairment within hours of using sildenafil. Since then, additional cases have been reported to the FDA related to sildenafil, tadalafil, and vardenafil. Fortunately, the number of cases is very small in relation to the millions of men who have used ED pills successfully. It's not clear that there is a cause-and-effect relationship between ED pills and NAION. At present, the concern is not great enough to prevent men from using these pills, but all men should use them carefully and responsibly. That means it should only be prescribed by a personal physician who really knows you. And it also means that scientists are investigating uses for the drug in patients with an array of vascular disorders having nothing to do with sexual function. They have nearly identical effects on ED as well as similar side effects.

1. How long does Viagra stay in your system?

It's the only nonsexual condition that has earned FDA approval for sildenafil. But since it's a serious problem, any benefit is most welcome. When we think of blood pressure, we usually think of the systemic circulation, of the blood pumped from the heart's left ventricle to the aorta and then to the smaller arteries that carry oxygen-rich blood throughout the body. But to pick up vital oxygen, blood must first pass from the less powerful right ventricle through the pulmonary artery to the lungs, then back to the left side of the heart. The pressures in the pulmonary artery are much lower (about 20/10 millimeters of mercury, or mm Hg) than in the aorta (lower than 120/80 mm Hg is considered healthy).

Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Exercise is the most common cause of rising pulmonary artery pressure, but the elevation is mild and subsides promptly with rest. High altitudes are another cause, which can lead to mountain sickness (see below). Far more serious are the large number of lung diseases, vascular diseases, heart disorders, and miscellaneous conditions that can cause pulmonary hypertension. And in primary pulmonary hypertension, no underlying cause is evident. Pulmonary hypertension causes shortness of breath, first during exertion but eventually at rest if the condition progresses.

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A variety of treatments are available, depending on the underlying problem. And the FDA has approved sildenafil (Revatio) in a dose strongest viagra pill of 20 mg three times a day for men and women with pulmonary hypertension. Clinical trials have demonstrated improved exercise tolerance with few side effects. Pulmonary hypertension is a feature of acute mountain sickness. High altitudes produce low blood-oxygen levels. Because they are newer drugs, scientists are just beginning to study them for problems that don't involve sexuality.

Other targets: Side effects

In most men with heart disease, it is. But several studies of patients with congestive heart failure also reported that the medication improves oxygen consumption, pulmonary artery pressure, and exercise capacity in these patients. Research shows that sildenafil helps the heart muscle relax properly, which could help patients with heart failure due to diastolic dysfunction. Another interesting property is sildenafil's ability to protect the heart from excessive stimulation by adrenaline. Clinical trials will be needed to see which patients might benefit. Sildenafil has already been licensed to treat men and women with pulmonary hypertension.

Condition	Risk Level	Recommended Action
Severe Heart Disease	High	Consult doctor before use
Nitrate medication use	Very High	Do not take Viagra without medical approval
Liver impairment	Moderate	Dose adjustment or avoid use
Vision loss (NAION)	High	Avoid or consult healthcare professional

Time will tell if any of these drugs will fill other potentials beyond promoting potency.