Guidelines for Using Vardenafil to Delay Ejaculation

One study from 1998 gave men with premature ejaculation 25 milligrams (mg) of sertraline daily, then 50 milligrams per day after three weeks, followed by 100 milligrams another three weeks later.

Precaution / Contraindication	Explanation	Alternative Actions
Nitrate medications	Contraindicated, risk of severe hypotension	Avoid Vardenafil with nitrate use
Severe cardiovascular disease	Increased risk of adverse events	Consult cardiologist before use
Liver impairment	May require dose adjustment	Lower dose or alternative therapy
Alcohol consumption	May increase side effects	Limit to reduce adverse effects

After taking a 25-milligram daily dose of sertraline, the men’s average ejaculation time increased from one minute to 7.6 minutes. Once the study participants started taking the higher 50-milligram daily dose of sertraline, their average ejaculation time increased to 13.1 minutes. At the 100-milligram dose, the men had an average ejaculation time of 16.4 minutes. At the 50- and 100-milligram doses of daily sertraline, a small number of participants started developing anejaculation (inability to orgasm during sex). Newer research has shown that SSRIs may help men last about three minutes longer during sex compared to a placebo.

• Vardenafil may improve overall sexual satisfaction.
• Men should report any adverse effects to their doctor.
• Taking Vardenafil 1 hour before sex is common.
• It can assist men with PE but is not a standalone solution.
• Lifestyle changes may also help manage PE symptoms.
• Combining medication with therapy increases effectiveness.
• Vardenafil's efficacy varies among individuals.
• Medical advice is crucial before starting Vardenafil for PE.
• Not recommended for men with certain cardiovascular conditions.
• Dose adjustments may be needed based on response.
• Vardenafil can be used with other ED treatments.
• Store Vardenafil at room temperature, away from moisture.

And they seem to improve key outcomes for men with premature ejaculation, including better control, more satisfaction during sex, and fewer symptoms. It’s possible that everyone’s favorite stay-hard pill may also function as a PE pill.

Access options

This effect is typically regarded as a side effect of medications like paroxetine and sertraline. But for folks with PE, this “adverse” effect can be beneficial. Healthcare professionals may also recommend combining an SSRI sex pills for women with a prescription ED medication such as Viagra or Cialis. They improve your sex life by increasing blood flow to your penis, helping you obtain and sustain erections. Some research also shows ED meds improve the perception of ejaculatory control — meaning you might feel like you have more control over when you orgasm.

Search strategy

We understand why you’d be a little concerned about taking a medication designed for one purpose to treat something else. But you might be surprised to learn that healthcare professionals often prescribe medications to treat issues outside their FDA-approved status. In fact, these off-label medications are surprisingly well-targeted when used to treat PE. Sexual experiences and sexual activity are very much mental exercises, but SSRIs don’t address the emotional element of sexual dysfunction. Instead, they make it harder for a person to reach orgasm.

Basic questions to ask your doctor

This may seem like an obvious conclusion, but research suggests the effect can help people with PE. You may have read about various medications like dapoxetine, fluoxetine, and others having this delayed-orgasm side effect. But one of the most commonly prescribed PE treatments in pill form is sertraline. SSRIs are among the most common medications for the treatment of premature ejaculation. Older research on sertraline shows that this medication can treat premature ejaculation symptoms when used daily — often by a significant amount. Research has found that many men with PE experience improvements after using ED medications like Viagra or generic sildenafil. In a 2007 study, researchers compared the effects of sildenafil, paroxetine (an SSRI) and the squeeze technique (a PE method that involves squeezing the penis during sex) to see which option best treated PE.

Product	Dosage	Quantity + Bonus	Price
Levitra Soft Tabs	20mg	120 + 8 Pills	288.52€ 274.78€	Buy
Viagra Generic	100mg	180 + 8 Pills	199.37€ 189.88€	Buy
Cialis Generic	60mg	270 + 10 Pills	443.96€ 422.82€	Buy
Cialis Generic	5mg	60 + 4 Pills	86.02€ 81.92€	Buy
Cialis Generic	60mg	10 Pills	41.22€ 39.26€	Buy
Kamagra Polo	100 mg	180 + 8 Pills	446.52€ 425.26€	Buy
Cialis Super Active	20mg	120 + 16 Pills	382.15€ 363.95€	Buy
Levitra Generic	60mg	120 + 8 Pills	372.33€ 354.60€	Buy
Cialis Generic	2.5mg	360 + 10 Pills	260.03€ 247.65€	Buy
Kamagra	100mg	180 + 6 Pills	436.79€ 415.99€	Buy
Levitra Generic	20mg	270 + 10 Pills	376.33€ 358.41€	Buy
Levitra Generic	10mg	10 Pills	28.93€ 27.55€	Buy
Cialis Professional	40mg	90 + 2 Pills	348.59€ 331.99€	Buy
Kamagra Soft Tabs	100 mg	32 Pills	120.11€ 114.39€	Buy

At the end of six months, sildenafil was shown to be the most effective treatment. Another study from 2005 found that although sildenafil didn’t directly increase the time before orgasm, it seemed to improve confidence and increase the perception of ejaculatory control. The researchers from the 2005 study also found that sildenafil reduces refractory time, making it easier for men with premature ejaculation to get a second erection shortly after sex. Research shows that PDE5 inhibitors work better than a placebo in helping with premature ejaculation.

• Vardenafil may cause a sensation of visual flickering.
• It can assist in cases of PE linked to performance anxiety.
• Proper hydration supports medication effectiveness.
• Combining Vardenafil with counseling may help extend benefits.
• Men should avoid excessive alcohol consumption.
• The recommended dose varies based on individual health.
• Some men notice a delay in ejaculation within 30 minutes.
• Not all men respond equally to Vardenafil.
• Safe use requires medical supervision.
• Vardenafil should not be mixed with other PDE5 inhibitors.
• Monitoring blood pressure is important during use.
• Use caution to prevent interactions with other drugs.

Combining a PDE5 inhibitor with an SSRI appears to be even more effective, helping men last longer than with an SSRI alone. Even if there’s no improvement in ejaculation time the first time you have sex, sildenafil might make it easier to enjoy round two with your partner.

This article is cited by

If you have premature ejaculation, you have an erection, but you reach orgasm and ejaculate earlier than you or your partner would like. Erectile dysfunction can lead to premature ejaculation. This happens because you know you can’t maintain an erection, leading to quick ejaculation so you don’t lose your erection. Because of this connection between these two conditions, your urologist will want to figure out if you have erectile dysfunction and, if so, treat that first. While it’s true that drinking alcoholic beverages can delay orgasm, it’s not a recommended treatment for premature ejaculation.

Mechanism of action and efficacy of clomipramine in the treatment of PE

There can be many reasons for premature ejaculation. Getting to the root cause of PE is the first step in finding the best treatment. Sometimes, treating the underlying cause — like depression or hormonal disorders — can be all you need to stop ejaculating early. Be sure to discuss all your options with a healthcare provider. Premature ejaculation is often easily treated with a few simple steps, so it’s important to see your provider if you’re experiencing premature ejaculation.

How it Works

Although it may be uncomfortable to talk about sexual problems, know that your providers want you and your partner to have a satisfying sex life. Your healthcare providers can come up with a plan to treat your premature ejaculation. Remember, this is a common problem and you’re not alone. Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more. Learn more about the Health Library and our editorial process. Like all medications, PDE5 inhibitors and SSRIs can cause potential side effects. For instance, potential side effects of sertraline include: Changes in sex drive (libido) or sexual performance Changes in sex drive (libido) or sexual performance Many of these are common potential side effects of all antidepressants.

• Vardenafil can sometimes cause visual disturbances.
• It does not cure PE but might delay ejaculation temporarily.
• Always follow prescribed dosing instructions.
• Use caution when combining with other medications.
• It is available by prescription only.
• Several factors influence Vardenafil's effectiveness.
• Men using Vardenafil should monitor side effects.
• It may improve self-esteem in men with PE.
• Some men report increased confidence in bed.
• Vardenafil may be less effective if taken with high-fat meals.
• Not suitable for men with certain eye conditions.
• Always consult a healthcare professional before use.

You can learn more about what to expect from SSRIs in our guide to antidepressant side effects. Sildenafil and other PDE5 inhibitors, on the other hand, generally only cause mild side effects while active in the body and when taken as prescribed. Changes in the ability to perceive color Changes in the ability to perceive color If you experience any of these side effects or are concerned about potential adverse effects, get in touch with your healthcare provider to discuss your options.

Symptoms and Causes of Premature Ejaculation

In some cases, healthcare providers may even prescribe phosphodiesterase type-5 inhibitors (PDE5 inhibitors) like sildenafil (the active ingredient in Viagra®) which are approved to treat erectile dysfunction (ED). If you want to prolong your erections, keep reading to explore the best pills for PE, topical medical treatments to consider, and why you should be cautious about over-the-counter treatments for PE. Premature ejaculation pills are an unofficial term for certain oral drugs healthcare providers prescribe off-label to treat premature ejaculation. These medications include SSRIs like sertraline and PDE5 inhibitors like sildenafil. Though these drugs are widely prescribed for PE and other sexual dysfunctions, they aren’t FDA-approved for these purposes.

Desensitizing agents

In fact, every PE fildena 120 medication is actually a pill originally intended for another purpose. Some of the top pills that might help you last longer in bed include: SSRIs like sertraline (commonly sold as Zoloft®) are popular among people with PE problems.These medications increase serotonin levels in the brain. Low serotonin levels in the brain are believed to play a role in premature ejaculation, whereas increased serotonin activity can delay orgasm. SSRIs like sertraline (commonly sold as Zoloft®) are popular among people with PE problems.These medications increase serotonin levels in the brain. Another commonly used PE pill is actually intended for another sexual dysfunction: ED.

Paroxetine (Paxil, Pexeva)

PDE5 inhibitors like sildenafil (Viagra), tadalafil (Cialis®), vardenafil (Levitra®), and avanafil (Stendra®) are sometimes prescribed off-label for premature ejaculation because they improve blood flow and the perception of ejaculatory control. We’ll go into more detail on how these pills work (and how well they work to improve sexual function) in the following sections. SSRIs are typically used to treat depression and anxiety. They regulate the amount of serotonin between neurons (the brain’s messengers), which is believed to help alleviate symptoms of depression. In some cases, healthcare providers might prescribe these drugs off-label for premature ejaculation since they help slow down orgasm and ejaculation. If your goal is to last longer during sex without prescription medication, some alternative treatments for PE are worth considering, either as part of a broader treatment plan or on their own.

Approach Considerations

Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards. Crowdis M, Leslie SW, Nazir S. Premature Ejaculation ( [Updated 2023 Feb 7]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Accessed 9/27/2023.

Off-Label Uses

Spontaneous sex for less than $2/day If you want to last longer in bed, premature ejaculation pills may be the answer. But we’re not talking about those sketchy male-enhancement supplements you can pick up at the gas station. A number of medications approved by the FDA (U.S. Food and Drug Administration) can help you gain better control of your erectile function. First, a reality check: Premature ejaculation (PE) is one of the most common male sexual health conditions, affecting as much as 30 to 75 percent of men worldwide (although reports are subjective and estimates vary widely).

Corresponding author

The point is, if you’re looking for oral medication or topical treatments to make you last longer, you’re definitely not alone. Keep scrolling for a rundown on how premature ejaculation is treated and the best PE pills to consider. Several treatments can help with premature ejaculation by delaying ejaculation, including locally applied anesthetics like lidocaine or benzocaine. But many of the so-called “premature ejaculation pills” are actually used off-label to treat PE. (Off-label use is when a product is used for something other than what it’s FDA-approved for.) PE pills include antidepressants like selective serotonin reuptake inhibitors (SSRIs).