Clinical Studies on Vardenafil's Safety and Efficacy
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The presence of other medical problems may affect the use of this medicine.
How Much Does Vardenafil Cost?
Patients should contact their healthcare provider for dose modification if they are not satisfied with the quality of their sexual performance with this drug, or in the case of an unwanted side effect. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Vardenafil is used to treat men with erectile dysfunction (sexual impotence). It belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly.
Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events
The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, avanafil helps to maintain an erection after the penis is stroked by increasing blood flow to the penis. Without physical action to the penis, such as that occurring during sexual intercourse, avanafil will not work to cause an erection.
Vardenafil Forms & Strengths
This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Make sure you tell your doctor if you have any other medical problems, especially: Abnormally shaped penis, including a curved penis and birth defects or Crowded disc or low cup to disc ratio in the eye (an eye disorder) or Hyperlipidemia (high fats in the blood) or Multiple myeloma (cancer of the blood) or Non-arteritic anterior ischemic optic neuropathy (NAION; serious eye condition), history of or Smoking—May increase the chance for a serious side effect in the eye called NAION.
- Common side effects include headaches and flushing.
- Serious side effects are rare but may include vision changes.
- Consult a doctor if you experience chest pain.
Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 6 months) or Retinitis pigmentosa (an inherited eye disorder) or Stroke, history of—Should not be used in patients with these conditions. Stomach ulcers—Chance of problems occurring may be increased. It is not known if the medicine is safe for use in these patients. Fructose intolerance—The Staxyn® disintegrating tablet contains sorbitol, which can make this condition worse.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Cialis Super Active | 20mg | 60 + 8 Pills | 230.32€ 219.35€ | |
| Kamagra 100 mg | 100 mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Cialis Generic | 5mg | 360 + 10 Pills | 268.08€ 255.31€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Kamagra Polo | 100mg | 84 + 4 Pills | 244.49€ 232.85€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Viagra Soft Tabs | 100mg | 60 + 6 Pills | 152.94€ 145.66€ | |
| Viagra Oral Jelly | 100mg | 10 Sachets | 46.36€ 44.15€ | |
| Cialis Generic | 2.5mg | 120 + 6 Pills | 128.93€ 122.79€ | |
| Levitra Soft Tabs | 20mg | 360 + 20 Pills | 682.21€ 649.72€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Kamagra Oral Jelly | 100 mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
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| Levitra Generic | 20mg | 20 Pills | 52.63€ 50.12€ |
QT prolongation (rare heart condition), or history of—Use with caution. The effects may be increased because of slower removal of the medicine from the body. Phenylketonuria (PKU)—The Staxyn® disintegrating tablet contains aspartame, which can make this condition worse. Use this medicine exactly as directed by your doctor.
| Side Effect | Frequency (%) | Severity | Management Tips |
|---|---|---|---|
| Headache | 15-20 | Mild | Hydration, OTC pain relievers |
| Flushing | 10-15 | Mild | Cooling measures, reassurance |
| Nasal Congestion | 8-12 | Mild to Moderate | Decongestants, monitor |
| Dizziness | 5-8 | Mild | Sit or lie down, avoid driving |
Do not use more of it and do not use it more often than your doctor ordered.
Alternative medication therapies
Mild hepatic dysfunction (Child-Pugh A): No adjustment recommended. Moderate hepatic dysfunction (Child-Pugh B): 5 mg orally once a day, as needed, approximately 60 minutes before sexual activity. The maximum dose should not exceed 10 mg. Severe hepatic dysfunction (Child-Pugh C): Use should be avoided. Comment: The orally disintegrating tablets should not be used in patients with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic dysfunction.
How Levitra works:
If taking potent or moderate inhibitors of CYP450 3A4, the dose should be adjusted as follows: Ritonavir: No more than 2.5 mg in a 72-hour period Indinavir, saquinavir, atazanavir, ketoconazole 400 mg daily, itraconazole 400 mg daily, clarithromycin: No more than 2.5 mg in a 24-hour period Ketoconazole 200 mg daily, itraconazole 200 mg daily, erythromycin: No more than 5 mg in a 24-hour period Safety and efficacy have not been established in patients younger than 18 years. This drug is not indicated for use in pediatric patients. This drug can be taken with or without food. The 10 mg orally disintegrating tablet (ODT) provides higher systemic exposure and is not interchangeable with the 10 mg film-coated tablets. The ODT tablet should be taken without liquid and immediately upon removal from the blister.
How does vardenafil work (mechanism of action)?
Patients who require a lower or higher dose than 10 mg should be prescribed the film-coated tablets. Patients treated with alpha-blockers, who have previously used vardenafil film-coated tablets, may be switched to ODT tablets at the advice of their healthcare provider. Patients should stop use of PDE5 inhibitors, including this drug, and seek medical attention in the event of sudden buy fildena 100 online loss of vision in one or both eyes, and decrease or loss of hearing. Symptoms related to postural hypotension may occur, appropriate countermeasures are recommended. Contact the prescribing physician if other antihypertensive drugs or new medications that may interact with this drug are prescribed by another healthcare provider. If you use too much, the chance of having unwanted effects is increased. This medicine should come with a patient information leaflet. Ask your doctor or pharmacist if you have any questions. You may take this medicine with or without food. This medicine usually begins to work within 60 minutes after taking it and stimulation of the penis is required.
- Vardenafil enhances blood flow to help achieve an erection.
- It does not cause automatic erections without sexual stimulation.
- Does not protect against sexually transmitted infections.
If you have any questions about the use of vardenafil, talk to your doctor. If you are using the disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack until you are ready to take the tablet. Peel back the foil and take the tablet out. Do not push the tablet through the foil. Place the tablet on your tongue and allow it to melt. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.
| Condition | Description | Alternative Action |
|---|---|---|
| Use of Nitrates | Can cause severe hypotension | Consult doctor for alternative meds |
| Severe Cardiovascular Disease | Increased risk during sexual activity | Medical evaluation required |
| Retinitis Pigmentosa | Potential risk of vision loss | Avoid use or discuss with an ophthalmologist |
| Hypotension (<90/50 mm Hg) | Low blood pressure at baseline | Monitor blood pressure carefully |
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
How do these drugs work?
If you are older than 65 or have liver problems, your doctor may start you on a lower dose of vardenafil hydrochloride tablets. If you have prostate problems or high blood pressure, for which you take medicines called alpha-blockers, your doctor may start you on a lower dose of vardenafil hydrochloride tablets. If you are taking certain other medicines your doctor may prescribe a lower starting dose and limit you to one dose of vardenafil hydrochloride tabletsin a 72-hour (3 days) period. An erection that won’t go away (priapism).If you get an erection that lasts more than 4 hours, get medical help right away. Color vision changes,such as seeing a blue tinge to objects or having difficulty telling the difference between the colors blue and green.
What should I do if I accidentally take too much vardenafil?
Store vardenafil hydrochloride tablets at room temperature 59° to 86°F (15° to 30°C). Keep vardenafil hydrochloride tabletsand all medicines out of the reach of children. Applies to the following strengths: 2.5 mg; 5 mg; 10 mg; 20 mg Initial dose: 10 mg orally once a day, as needed, approximately 60 minutes before sexual activity. Increase to 20 mg or decrease to 5 mg based on efficacy and tolerability. Maximum dose: 20 mg once a day Initial dose: 5 mg orally once a day Sexual stimulation is required for a response to treatment.
Can I buy Levitra over the counter?
A time interval between dosing should be considered when administering this drug concomitantly with alpha-blockers. Patients taking alpha-blockers should not initiate vardenafil therapy with the orally disintegrating tablet. Initial dose: 5 mg orally once a day, as needed, approximately 60 minutes before sexual activity Comments: Sexual stimulation is required for a response to treatment. CrCl: 30 to 80 mL/min: No adjustment recommended. Comment: The orally disintegrating tablet (brand Staxyn) can be used in patients with mild, moderate or severe renal impairment. The dose of this medicine will be different for different patients.
How to Get a Prescription for Vardenafil
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may cenforce 100mg tablet be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Follow your doctor's orders or the directions on the label.
Side Effects
For non-prescription products, read the label or package ingredients carefully. Vardenafil is not indicated for use in children. Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of vardenafil in the elderly. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
Other Examples of PDE5 Inhibitors
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.